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The efficacy and safety of different dosage low molecular heparin in post-operative period of total hip /knee arthroplasty under the management of enhanced recovery after surgery: a double-center prospective study

The efficacy and safety of different dosage low molecular heparin in post-operative period of total hip /knee arthroplasty under the management of enhanced recovery after surgery: a double-center prospective study

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900027434
Enrollment
Unknown
Registered
2019-11-13
Start date
2019-11-13
Completion date
Unknown
Last updated
2019-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hip and knee joint disease

Interventions

A:LMWH 0.4 ml qd
B:LMWH 0.2 ml qd

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: All patients undergoing primary total hip/knee arthroplasty during study period.

Exclusion criteria

Exclusion criteria: Preoperative hepatic or renal dysfunction; preoperative use of anticoagular medication seven days prior to surgery; history of fibrinolytic disorder or blood dyscrasia; cerebrovascular accident, myocardial infarction, New York heart association class III or IV heart failure, atrial fibrillation, history of deep vein thrombosis or pulmonary embolus, preoperative INR > 1.4, aPTT >1.4 x normal, platelets < 140000/mm3.

Design outcomes

Primary

MeasureTime frame
total blood loss;hidden blood loss;Hb drop;transfusion;coagulation indicator (PT, APTT, INR);TEG;antifactor Xa activity;incidence of thrombosis (DVT PE);—

Secondary

MeasureTime frame
incision related complications;readmission rate;ecchymosis;massive haemorrhage;range of motion;—

Countries

China

Contacts

Public ContactFuxing Pei

West China Hospital of Sichuan University

peifux@126.com+86 13258327318

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026