pulmonary tuberculosis
Conditions
Interventions
Sponsors
Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Mycobacterium tuberculosis in sputum (rifampicin resistant) was diagnosd positive by Xpert PCR; 2) BD960 Mycobacterium tuberculosis in sputum was positive for Mycobacterium tuberculosis; 3) The drug sensitivity test of BD960 showed that isoniazid and rifampicin were resistant simultaneously; 4) Conform to the established TCM syndrome standard; 5) Aged 18 to 65 years. 6) Accept the drug treatment voluntarily and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) ten items of BD drug sensitivity exclude XDR-TB; 2) the continuous course of disease was more than 5 years and the number of retreatment times was more than 2 times in the past; 3) chest CT showed that the diameter of pulmonary cavity was more than 5cm or the number of cavities was more than 5; 4) with the history of massive hemoptysis; 5) body mass index (BMI) was less than 19; 6) tuberculosis but not Pulmonary tuberculosis, such as lymphoid tuberculosis, bone tuberculosis and brain tuberculosis; 7) family history of mental disease; respiratory failure; severe peptic ulcer; malignant tumor; AIDS; autoimmune disease; 8) legally disabled patients; 9) do not take oral medication; 10) pregnant, preparing pregnant or lactating women; 11) those who are allergic to the test drug and its components; 12) QT interval in ECG is greater than 500 ms after correction; 13) patients with abnormal liver function (ALT more than 1.2 times of the upper limit of normal), or positive for HBsAg, HBeAg and HBcAg at the same time; 14) poor control of blood glucose in diabetic patients (fasting blood glucose > 7mmol/L, postprandial blood glucose > 11mmol/L); 15) the researchers determined that the patients could not complete the treatment in the trial period because of the existence risk of other diseases; 16) those who cannot judge the efficacy or incomplete data, which affect the efficacy or safety judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Height;Weight;age;Negative conversion rate of Mycobacterium tuberculosis in sputum culture;Local absorptivity;cavities closen rate;cure rate;Adverse reaction rate;Improvement rate;survival time; | — |
Countries
China
Contacts
Public ContactLU Zhenhui
Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed