cervical carcinoma
Conditions
Interventions
Single arm:PEG-rhG-CSF
Sponsors
Gansu Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 and = 70; 6. There was no obvious sign of hematological system disease, ANC >=1.5x 10^9 / L, platelet count >= 80 x 10^9 / L, Hb >= 90 g / L, and no bleeding tendency; 7. Patients sign informed consent.
Exclusion criteria
Exclusion criteria: 1. At present, there are uncontrollable infections or systemic antibiotic treatment within 72 hours before chemotherapy; 2. Any myelodysplasia or other hematopoiesis abnormality; 3. Patients who have received bone marrow or hematopoietic stem cell transplantation in the past 3 months; 4. The patients who had other malignant tumors before were not cured or had brain metastasis; 5. There is no serious cardiovascular disease such as cerebrovascular accident, myocardial infarction in recent 6 months, hypertension, unstable angina, heart failure (NYHA 2-4 grade) and arrhythmia requiring drug intervention; 6. Total bilirubin (TBIL), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in liver function test were all more than 2.5 times of the upper limit of normal value; 7. Renal function test: serum creatinine (CR) > 1.5 times the upper limit of normal value; 8. Those who are allergic to this product or other biological products from genetically engineered Escherichia coli; 9. Those who suffer from mental or nervous system diseases and cannot cooperate; 10. The researchers think it is not suitable for the participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of grade III / IV neutropenia in each cycle supported by PEG rhG CSF; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of neutropenic fever (FN) supported by PEG rhG CSF;Proportion of dose adjustment of chemotherapy drugs caused by neutropenia in each cycle under the support of PEG rhG CSF;The incidence of delayed chemotherapy caused by neutropenia in each cycle supported by PEG rhG CSF;Antibiotic utilization rate in each cycle supported by PEG rhG CSF; | — |
Countries
China
Contacts
Public ContactZhao Fengju
Gansu Cancer Hospital
Outcome results
None listed