hemodialysis
Conditions
Interventions
treatment group:regional citrate anticoagulatio
Control group:heparin-free hemodialysis
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients who receive maintenance hemodialysis because of renal failure. 2. Aged between 18 to 70 years old; 3. There is active bleeding or high risk of bleeding (such as gastrointestinal bleeding, cerebral bleeding, bleeding at the surgical site, etc.), and heparin or low molecular weight heparin should not be used for anticoagulation. 4. The hemoglobin level between 70 to120g/L; 5. The platelet levels between 100 to 350 x 10^9/L; 6. The blood calcium level 1.8~2.5mmol/L; 7. The Vascular access type is arteriovenous autologous fistula or deep venous indentation catheter; 8. Stable hemodynamics; 9. Clear consciousness; 10. Normal cognition and high compliance, and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. A history of sodium citrate allergies; 2. With liver cirrhosis or significant impairment of liver function; 3. Extensive muscle tissue injury or hypoperfusion of muscle tissue; 4. Oxygen inhalation by mask or oxygenation index <300mmHg is required; 5. Hemophilia or other coagulopathies; 6. With severe systemic infections; 7. Patients who can not cooperate because of mental illness ; 8. Any other conditions that the researchers think the subject can't attend the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fiter and venous trap clotting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;Blood chemistry;blood gas analysis;PT;APTT;metabolic alkalosis; | — |
Countries
China
Contacts
Public ContactZhang Ling
Nephrology Department, West China Hospital, Sichuan University
Outcome results
None listed