Depressive Disorder
Conditions
Interventions
Case series:Nil
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male or female outpatients aged at least 18 years and not more than 65 years; 2. Has a diagnosis of major depressive disorder by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria(comfimed by MINI); 3. Systemic anti-depressants treatment were not adopted during current episode, or has taken anti-depressants less than 7 days in last 14 days; 4. Total scord of QIDS-SR16 >=11 and HAMD-17 >=20 at enrolment in open-label preliminary phase; 5. Has at least primary school education and can understand the scales; 6. Prepareing to use escitalopram or venlafaxine sustained release tablets or mirtazapine; 7. Signed an informed consent form by patients.
Exclusion criteria
Exclusion criteria: 1. History of manic episode hypomanic episode; 2. History of bipolar, schizophrenia, schizoaffective disorder, or other psychotic disorders; 3. History of drug and alcohol dependence or acute intoxication; 4. Women in pregnancy or lactation; 5. Significant risk of suicidal behaviors, HAMD-17 Item 3(suicide) score >=3; 6. Current clinically significant disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effective rate;Inflammatory factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| resting state functional magnetic resonance imaging, rs-fMRI; | — |
Countries
China
Contacts
Public ContactGang Wang
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed