Refractory hypertension
Conditions
Interventions
Group A:Phase I: Low-sodium dialysis combined with antihypertensive therapy
phase II: Standard sodium dialysis combined with antihypertensive therapy.
Group B:phase I: Standard sodium dialysis combined with antihypertensive therapy
Phase II: Low-sodium dialysis combined with antihypertensive therapy.
Sponsors
The Eighth Affiliated Hospital, Sun Yat-Sen University (Shenzhen Futian)
Eligibility
Sex/Gender
All
Age
30 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. understand and have signed the informed consent; 2. diagnosis as chronic renal failure and have undergone maintenance hemodialysis for more than 1 year, aged >30 years, with hypertension; 3. with optimal or best-tolerated doses of three or more antihypertensive drugs, pressure fails to lower office < 140/90mmHg; 4. no cardiovascular and cerebrovascular events in four weeks; 5. can swallow pills and receive subcutaneous injections; 6. negative pregnancy test and willing to contraception during treatment.
Exclusion criteria
Exclusion criteria: 1. pregnancy, breastfeeding or malignant tumor; 2. do not reach the ideal dry weight or blood pressure is unstable; 3. hypotension; 4. with acute heart failure or arrhythmia; 5. no legal capacity or legal capacity is restricted; 6. disagree for the participation from researchers; 7. severe heart, liver or lung dysfunction; 8. poor adherence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic pressure;Diastolic pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrocardiogram;Echocardiography;Blood routine;Liver function;Renal function; | — |
Countries
China
Contacts
Public ContactHuang Hui
The Eighth Affiliated Hospital, Sun Yat-Sen University (Shenzhen Futian)
Outcome results
None listed