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Study of cerebral network connectivity-based cut-off and mechanism of decision-making rTMS in chronic subcortical stroke patients with hemiplegia using a multimodal fMRI

Study of cerebral network connectivity-based cut-off and mechanism of decision-making rTMS in chronic subcortical stroke patients with hemiplegia using a multimodal fMRI

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900027399
Enrollment
Unknown
Registered
2019-11-12
Start date
2020-01-01
Completion date
Unknown
Last updated
2019-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

high frequency rTMS:high frequency rTMS on cPMd
sham rTMS:coil placed on cM1 vertically

Sponsors

Huashan Hospital, Fudan University, Shanghai, China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) diagnosed by computed tomography or MRI as first-ever subcortical ischemic or hemorrhagic stroke between 3 months to 12 months following stroke onset; (2) no significant cognitive impairment (MMSE >= 27); (3) age between 18 and 80 years; (4) unilateral upper limb and hand hemiplegia (Modified Brunnstrom classification as grade I-IV); (5) right handed according to the Edinburgh Handedness Inventory.

Exclusion criteria

Exclusion criteria: (1) severe spasticity (Modified Ashworth Spasticity Scale > 2) of the affected upper extremity; (2) significant pain on the affected side (Ten-point Visual Analog Scale > 4); (3) excessive sensory disturbance, aphasia, neglect, or apraxia; (4) active malignant disease or multiple organ failure; (5) still enrolled in any rehabilitation or drug studies; (6) metal implant, magnetic sheet or cardiac pacemaker; (7) epilepsy.

Design outcomes

Primary

MeasureTime frame
FM-UL;ARAT;WMFT;NIHSS;MBI;MEP;Brunnstrom;MMT;MAS;

Countries

China

Contacts

Public ContactLimin Sun

Huashan Hospital, Fudan University

tracy611@sina.com+86 13611689182

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 18, 2026