delirium
Conditions
Interventions
general anesthesia :general anesthesia
regional anesthesia:regional anesthesia
Sponsors
Department of Anesthesiology, Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: patients=65 years old; hospital admission for surgery for hip fracture; ASA physical status classification I-III.
Exclusion criteria
Exclusion criteria: Parkinson disease; all-cause dementia (including PD related dementia, AD related dementia and lewys body dementia); a stroke in the prior 6 months or any other central nervous system (CNS) disease; preoperative delirium;severe deafness or vision problems, linguistic barriers, illiteracy, and/or communication difficulties; patients with alcohol-related disorders, multiple trauma or multiple fractures; ASA physical status classification >III;shift work or taking medications affecting melatonin; transfer to ICU postoperatively, unexpected discharge and refuse to participate in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melatonin concentration;Postoperative delirium incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cortisol concentration;Tumor necrosis factor-alpha concentration;Interleukin-6 concentration;Sleep quality after the surgery;The intensity of pain at rest and with movement after the surgery;Cognitive function after surgery(assessed with TICS-m);Interleukin-1 concentration;The subtype, severity, and duration of delirium after the surgery;Length of stay in hospital after surgery;The survial duration within one year after surgery;Non-delirium complications; | — |
Countries
China
Contacts
Public ContactXiangyang Guo
Peking University Third Hospital
Outcome results
None listed