Adrenal Disease
Conditions
Interventions
Gold Standard:At present, the main classification methods are adrenal CT and bilateral adrenal vein (AVS).
flora, 
blood 
acid.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) the United States in 2016 "the original aldehyde disease diagnosis and treatment guidelines" and the Chinese medical association of endocrinology branch to complete Chinese original aldehyde disease expert consensus recommendations: ARR screening positive patients need to accept one or more than 1 confirmatory test to confirm or exclude the diagnosis of PA, but for the spontaneous hypokalemia, plasma renin below detection limit or the plasma aldosterone levels greater than 20 ng/dL (550 pmol/L) in patients with confirmed that don't have to test. (2) 28 kg/m2 or higher BMI; 20 kg/m2 or (3) through medical history inquiry, physical examination, electrocardiogram examination, skull imaging examination and other data exclude obvious cardiovascular and cerebrovascular diseases; (4) mental normal, after informed consent to participate in the research.
Exclusion criteria
Exclusion criteria: (1) with acute and chronic liver, renal insufficiency, cholestasis;Acute infectious disease;Malignant tumor;Thyroid disease;Diseases of the immune system;Patients with gastrointestinal diseases; (2) with serious mental illness and cognitive impairment; (3) treatment before the use of drugs that have an impact on this study; (4) the study of drug allergy, drug side effects can not tolerate, do not want to take biological specimens; (5) pregnant and lactating women; (6) the use of antibiotics, probiotics and other intestinal flora intervention drugs, health care products, etc..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota16sRNA;Fecal bile acids;Blood bile acid;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactChen Tao
Department of Endocrinology, West China Hospital, Sichuan University
Outcome results
None listed