Schizophrenia
Conditions
Interventions
Group 1:Empirical antipsychotics treatment
Group 2:MRI guided antipsychotics selection
Healthy control group (not randomized):None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
16 Years to 45 Years
Inclusion criteria
Inclusion criteria: The diagnosis of schizophrenia were deterined by the consensus between two experienced psychiatrists using the Structured Clinical Interview for DSM-IV (SCID)–Patient Version. And healthy controls undergo Structured Clinical Interview for DSM-IV Non-Patient Edition to exclude the lifetime absence of psychosis. The inclusion criteria for schizophrenia are: 1. Age between 16 and 45 years; 2. Right handed; 3. Above primary school level of education; 4. The time from initial onset to treatment between 1 month to 2 year; 5. Free from antipsychotics and mood stabilizer; 6. Volunteer to take part in this project and sign the informed consent; The inclusion criteria for healthy controls are: 1. Risidents in the local place as patients live; 2. Age, gender, education year and social status matched healthy controls; 3. No history of psychosis in the first-degree relatives.
Exclusion criteria
Exclusion criteria: 1. Contraindication of MRI examination 2. Existence of a neurological disorder; 3. Alcohol or drug abuse; 4. Pregnancy; 5. Any physical illness such as a brain tumor, hepatitis, or epilepsy as assessed according to clinical evaluations and medical records.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive And Negative Syndrome Scale, PANSS;Global Assessment of Functioning,GAF;Brief Assessment of Cognition in Schizophrenia, BACS; | — |
Countries
China
Contacts
Public ContactSu Lui
West China Hospital, Sichuan University
Outcome results
None listed