Parkinson's disease
Conditions
Interventions
Gold Standard:British brain bank Parkinson's disease diagnostic criteria
of 
to 
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Sponsors
The First Affiliated Hospital of Chengdu Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Parkinson's disease group 1) Aged 50 to 80 years; 2) Neurology physicians in clinical outpatient and inpatient departments are strictly screened according to the diagnostic criteria for Parkinson's disease in the British brain bank; 3) The informed consent form contains all the contents of this study and volunteers to participate in the study. 2. Non-Parkinson Group 1) Aged 50 to 80 years; 2) It is planned to randomly select patients with non-Parkinson's disease who are matched with their ages from the Department of Neurology, First Affiliated Hospital of Chengdu Medical College; 3) The informed consent form contains all the contents of this study and volunteers to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Patients with secondary Parkinson's syndrome and other Parkinson's superposition syndrome; 2. Patients with any ocular surface disease or systemic metabolism may also affect diseases of the tear film structure; 3. Combined with heart, lung, liver, kidney, endocrine, serious diseases of the blood system; 4. Acute or chronic infection, systemic inflammation, autoimmune or neoplastic disease; 5. Long-term use of any systemic treatment that may affect the testing of tears, such as: steroids, hormonal drugs (hormone replacement therapy), beta-blockers, anticholinergics and amantadine; 6. Suffer from aphasia, severe dysarthria and other diseases that affect clinical evaluation; 7. Exclude other diseases associated with a-Syn, such as Lewy body dementia, acute cerebrovascular disease, and prion disease; 8. Severe anxiety, depression, and schizophrenia, and mental illness through cognitive function or subsequent examination; 9. Use diuretics, anti-inflammatory drugs, antineoplastic agents, corticosteroids, immunosuppressants, antidepressants or anxiolytics in the past 2 months; 10. Compliance is poor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a-synuclein;optical coherence tomography;SEN, SPE, ACC, AUC of ROC; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Fields;Intraocular pressure;Medical history;Anxiety and depression;The severity of Parkinson disease;Non-motor symptoms;Imaging inspection; | — |
Countries
China
Contacts
Public ContactXianwei Zou
Department of Neurology, the First Affiliated Hospital of Chengdu Medical College
Outcome results
None listed