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Efficacy of using dexmedetomidine combined with ropivacaine to quadratus lumborum block for postoperative analgesia in patients undergoing laparoscopic hysterectomy

Application of dexmedetomidine combined with ropivacaine for quadratus lumborum block in the rapid recovery of patients after laparoscopic hysterectomy

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900027300
Enrollment
Unknown
Registered
2019-11-08
Start date
2020-02-01
Completion date
Unknown
Last updated
2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative analgesia

Interventions

Ropivacaine group:quadratus lumborum block with 0.2% ropivacaine
Low dose dexmedetomidine group:quadratus lumborum block with 0.2% ropivacaine combined with 0.25 ug/kg dexmedetomidine
Middle dose dexmedetomidine group:quadratus lumborum block with 0.2% ropivacaine combined with 0.5 ug/kg dexmedetomidine
High dose dexmedetomidine group:quadratus lumborum block with 0.2% ropivacaine combined with 0.75 ug/kg dexmedetomidine

Sponsors

Jieyang People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosed as "uterine fibroids", undergoing laparoscopic hysterectomy 2. Aged 18 to 65 years 3. Body mass index was 18 to 25 kg/m2 4. The American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) is I or ? level 5. Patients who voluntary participation in clinical trials and signed the informed consent form

Exclusion criteria

Exclusion criteria: Combined with malignant tumor,hypertension, diabetes,heart disease, adrenal gland diseases and severe hepatic and renal dysfunction; combined with chronic pain and bradycardia; long-term use of corticosteroids, analgesics, adrenergic agonists and antagonists; alcohol, nicotine and opioid dependence; local anesthetics allergy; turn to laparotomy; fail to quadratus lumborum block.

Design outcomes

Primary

MeasureTime frame
VAS scores in rest;VAS scores during coughing;sedation scores;plasma cortisol;blood glucose;BCS Comfort rating;Quality of recovery;QoR -15 scale;

Secondary

MeasureTime frame
postoperative analgesia satisfaction;

Countries

China

Contacts

Public ContactLongsheng Zhang

Jieyang People's Hospital

13925603360@163.com+86 13925603360

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026