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Dose-escalation by Hypofractionated Simultaneous Integrated Boost Intensity-modulated Radiotherapy (SIB-IMRT) in Unresectable Stage ? Non-small-cell Lung Cancer

Dose-escalation by Hypofractionated Simultaneous Integrated Boost Intensity-modulated Radiotherapy (SIB-IMRT) in Unresectable Stage ? Non-small-cell Lung Cancer

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900027290
Enrollment
Unknown
Registered
2019-11-08
Start date
2012-04-01
Completion date
Unknown
Last updated
2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

4 groups:Dose-escalation

Sponsors

Shanghai Chest Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Eligible patients with histologically or cytologically confirmed NSCLC, classified as unresectable stage III (according to American Joint Committee on Cancer [AJCC; 6th edition]). Patients must previously untreated, with no prior thoracic radiation or chemotherapy. The age of enrolled patients ranged between 18-75 years old. The Eastern Cooperative Oncology Group (ECOG) performance status (PS) of the patient was 0–1, weight loss was less than 10%, and the expected survival time was more than 3 months.

Exclusion criteria

Exclusion criteria: Patients had another malignant tumor history that had been clinically cured in 5 years Patients who were pregnant, breastfeeding, had severe lung and heart diseases that affected lung function, and could not endure concurrent chemotherapy assessed by a medical oncologist due to medical reasons.

Design outcomes

Primary

MeasureTime frame
the maximum-tolerable dose (MTD);

Countries

China

Contacts

Public ContactXiaolong Fu

Shanghai Chest Hospital

xlfu1964@hotmail.com+86 15801831535

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 13, 2026