Cervical Cancer
Conditions
Interventions
experimental group:standard chemoradiotherapy± boost in local tumor bed
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Cervical cancer patients with whole layer or above myometrial infiltration after early cervical cancer radical resection.; 2. Aged 18 to 65 years; 3. ECOG performance status 0 - 2; 4. Histological diagnosis of squamous cell carcinoma, adenocarcinoma or adenosquamous cell carcinoma of the cervixWBC >=3.0 x 10^9/L and ANC >=2.0 x 10^9/L; Platelets >=100 x 10^9/L; Bilirubin =60ml/min or >=50 ml/min by EDTA creatinine clearance; 6. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. postoperative positive parametrial and/or surgical margins; 2. Previous radiotherapy and/or chemotherapy for this tumor; 3. Patients with bilateral hydronephrosis unless at least one side has been stented and renal function fulfils the required inclusion criteria; 4. Evidence of distant metastases; 5. Prior diagnosis of Crohns disease or ulcerative colitis; 6. Patients with other invasive malignancies; 7. Patients who are pregnant or lactating; 8. Any contraindication to the use of cisplatin chemotherapy; 9. Serious illness or medical condition that precludes the safe administration of the trial treatment including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements; 10. HIV positive.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;adverse effect; | — |
Countries
China
Contacts
Public ContactWu Xiaohua
Fudan University Shanghai Cancer Center
Outcome results
None listed