Effect of propofol on the reaction time of rocuronium compared with desflurane and sevoflurane

A randomized controlled large-sample prospective study for the effect of desflurane versus sevoflurane on the aging effect of propofol on rocuronium

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900027234

Enrollment

Unknown

Registered

2019-11-06

Start date

2019-11-15

Completion date

Unknown

Last updated

2019-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effects of inhalation anesthesia on muscle relaxation

Interventions

Desflurane group:Monitoring of muscle relaxation during desflurane inhalation anesthesia

Sevoflurane group:Monitoring of muscle relaxation during sevoflurane inhalation anesthesia

Propofol intravenous group:Monitoring of muscle relaxation during intravenous anesthesia with propofol

Eligibility

Sex/Gender

Female

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Aged 18-55 years; ASA grade I or II; BMI: 18-25; sign the informed consent of anesthesia.

Exclusion criteria

Exclusion criteria: Postpone the operation; those who have organ dysfunction such as heart, lung, liver and kidney; those who have neuromuscular diseases; those who use other drugs that affect the metabolism of rocuronium before operation; those who may have difficulty in ventilation and intubation of face mask; those who are allergic to experimental drugs or who are suspected of having a family history of malignant hyperthermia.

Design outcomes

Primary

Measure	Time frame
Clinical effect time;Onset time of muscle relaxation;Muscle relaxation recovery index;	—

Countries

China

Contacts

Public ContactGao Jiandong

Beijing Chaoyang Hospital, Capital Medical University

wuzh0308@ccmu.edu.cn+86 13701163323

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026