primary testicular diffuse large B cell lymphoma
Conditions
Interventions
Case series:intensive CNS prophylaxis
Sponsors
West China Hospital
Eligibility
Sex/Gender
Male
Age
15 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 15-75 years; 2. Newly diagnosed and untreated primary testicular diffuse large B cell lymphoma; 3. Orchiectomy is performed and within 2 months before study enrollment; 4. Ann Arbor Stage IE and IIE; 5. Hematological counts: ANC > 1.5 x 10^9/L and PLTs count > 75 x 10^9/L; 6. Cardiac ejection fraction >=45% by echocardiography; 7. No underlying disease that may preclude chemotherapy; 8. Conjugated bilirubin =45 ml/min; 11. HIV and HCV negativity; 12. No signs of active chronic hepatitis B; 13. Life expectancy > 6 months; 14. Performance status < 2 according to ECOG scale; 15. Understanding the trial and writing informed consent.
Exclusion criteria
Exclusion criteria: 1. Secondary testicular lymphoma; 2. CNS involvement by lymphoma; 3. History of other malignant diseases with the exception of patients with complete remission >=5 years; 4. Post-transplant lymphoproliferative disorders; 5. Hypersensitivity or intolerance to any agent of chemotherapy; 6. Liver or renal insufficiency or other diseases that preclude chemotherapy; 7. Uncontrolled or severe cardiovascular disease including myocardial infarction within 6 months of entry, New York Heart Association (NYHA) Class III or IV heart failure; 8. Uncontrolled hypertension or diabetes; 9. Have participated in other clinical trial.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| relapse rate in CNS;progress-free survival;Overall survival; | — |
Primary
| Measure | Time frame |
|---|---|
| safety;feasibity; | — |
Countries
China
Contacts
Public ContactHongbing Ma
West China Hospital, Sichuan University
Outcome results
None listed