Effect of Methoxamine and Ephedrine on Cerebral Oxygen Saturation During Carotid Endarterectomy: a Randomized Controlled Trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900027214

Enrollment

Unknown

Registered

2019-11-05

Start date

2020-06-01

Completion date

Unknown

Last updated

2019-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid endometrial atherosclerotic plaque

Interventions

Intervention group 1:methoxamine boosts blood pressure

Intervention group 2:ephedrine boosts blood pressure

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) Selective general anesthesia for carotid endarterectomy; 2) Age 18-65 years; 3) ASA rating I-II.

Exclusion criteria

Exclusion criteria: 1) Refusal to participate in this study; 2) The mean arterial pressure drop is less than 20% compared with the baseline value; 3) Emergency surgery; 4) Severe arrhythmia, heart failure; 5) Liver and kidney dysfunction. 6) Allergic to methoxamine and ephedrine

Design outcomes

Primary

Measure	Time frame
Hemodynamic index;cerebral oxygen saturation;	—

Countries

China

Contacts

Public ContactAi Yanqiu

The First Affiliated Hospital of Zhengzhou University

aiyanqiu82@163.com+86 13027501732

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026