Chronic hepatitis B virus infection
Conditions
Interventions
Treatment group:peginterferon monotherapy
Control group:do not receive antiviral therapy
Sponsors
The Second Affiliated Hospital of Xi’an Jiaotong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 18 years to 65 years; 2) Serum HBsAg positive for over 6 months; 3) Quantitative HBsAg <= 3000 IU/mL,HBeAg negative, HBV DNA < 2.0x10^3 IU/mL, 4) Normal alanine aminotransferase (ALT) concentration 5) White blood counts (WBC) in a range of 4-10x10^9/L, platelet counts (PLT) in a range of 100-300 x 10^9/L; 6) Patients signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients had hepatitis A virus, hepatitis C virus, hepatitis D virus or human immunodeficiency virus (HIV) co-infection; 2) Patients had other chronic liver diseases (eg, alcoholic liver disease, autoimmune hepatitis, severe metabolic liver disease, toxic liver disease); 3) Cirrhosis or decompensated cirrhosis, 4) Tumors of other systems; 5) Severe complication in other organs; 6) Sever thyroid dysfunction or diabetes; 7) History of severe depression or known severe psychiatric disease; 8) Drug abuse; 9) Pregnant women and lactating women or patients who have pregnancy plans and are unwilling to contraception during the study period; 10) Allergyto interferon or a component of the tested product; 11) Participate in other clinical researchers at the same time; 12) The investigators considered it inappropriate for patients to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBsAg quantification;HBsAb quantification; | — |
Secondary
| Measure | Time frame |
|---|---|
| HBV DNA quantification;ALT;AST; | — |
Countries
China
Contacts
Public ContactShuangsuo Dang
The Second Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed