Chronic Periodontitis
Conditions
Interventions
Experimental Group1:Dental pulp stem cell complex + Bio-Oss bone meal
Experimental Group2:Dental pulp stem cell + exosome complex + Bio-Oss bone meal
Control group:Bio-Oss bone meal
Sponsors
College of Stomatology,Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1) Age 18 to 55 years old; 2) at least one tooth in the mouth has a 2 or 3 wall vertical type intrabony defects with PD>=5mm and the imaging bone defect depth is >=3mm; 3) The tooth looseness studied is within II (including II degree), and there is enough attachment width to meet GTR and bone grafting; 4) There are teeth in the patient's mouth that can remove healthy pulp tissue (such as impacted wisdom teeth or non-functional teeth); 5) After guidance, have a good sense of oral care; 6) Those who understand the purpose of this study and agree to sign the informed consent form. [Note] Imaging depth of the inner wall defect refers to the linear distance between the highest point and the lowest point of the bone defect on the X-ray film.
Exclusion criteria
Exclusion criteria: 1) Smokers (more than 10 in the past 3 months); 2) Patients with systemic diseases who cannot undergo surgery are not included. For example, patients with acute heart attack within six months, patients with rheumatic heart disease, patients with blood diseases, patients with uncontrolled diabetes (fasting blood glucose >8.88mmol/L), patients with infectious diseases, history of malignant tumors, and people with mental disorders And severely malnourished (serum albumin concentration <2 g/dL)); 3) Allergies and history of allergies to blood products; 4) breastfeeding, pregnant women; 5) taking calcium antagonists 4 weeks before surgery; 6) Those who need to take adrenal corticosteroids within 4 weeks after surgery; 7) are participating in other clinical trials; 8) Others of this project believe that the test does not meet the requirements of this test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bone defect depth (BDD); | — |
Secondary
| Measure | Time frame |
|---|---|
| probing depth (PD);clinical attachment loss (CAL);gingival recession (GR); | — |
Countries
China
Contacts
Public ContactLi Ang
College of Stomatology, Xi'an Jiaotong University
Outcome results
None listed