postoperative pain
Conditions
Interventions
placebo group:preoperative oral placebo
pregabalin group:preoperative oral placebo 150mg
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing craniotomy via temporal approach; 2. Intracranial space occupying lesions (diameter less than 5cm); 3. Aged 18-65 years; 4. ASA I or II; 5. The operation time was about 5 ± 1 h.
Exclusion criteria
Exclusion criteria: 1. Preoperative VAS score was greater than 0. 2. Preoperative nausea and vomiting; 3. Allergic to pregabalin; 4. Those who are currently taking drugs that may interact with the research drugs; 5. Patients who participated in other clinical studies in the past 30 days; 6. BMI>30; 7. Pregnant or lactating patients; 8. Patients with renal insufficiency (creatinine clearance rate less than 60ml / min); 9. Previous history of heart disease and arrhythmia; 10. Patients with a history of alcohol or drug abuse; 11. Patients with mental or consciousness disorders; 12. Patients with consciousness or mental disorder, aphasia and hearing impairment after operation; 13. It is necessary to operate again due to intracranial hemorrhage or serious brain edema; 14. Patients with non central nervous system tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the VAS scores on movement (moving head) at 6 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| the VAS scores on movement (moving head) at 24 hours after surgery;the VAS scores on movement (moving head) at 48 hours after surgery;headache and VAS score;Ramsay sedation scale/scores (RSS);nausea;Vomiting;the dosage of analgesic;the dosage of rescue antiemetic; | — |
Countries
china
Contacts
Public ContactJiuhong Liu
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed