Sepsis shock
Conditions
Interventions
experimental group:Hydroxylamine
control group:Noradrenaline
Sponsors
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Eligibility
Sex/Gender
Male
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Sign informed consent; 2. At least 18 years old; 3. Meet the diagnosis process and specific criteria of septic shock (3.0). 4. The use time of noradrenaline / dopamine before enrollment is less than 4h.
Exclusion criteria
Exclusion criteria: 1. Acute coronary syndrome (acute myocardial infarction during shock, confirmed by the patient's history, ECG or changes of myocardial Enzymology); 2. In the current ICU, hydroxyamine was used for arterial blood pressure support before admission. 3. Patients with irreversible or dying conditions determined by researchers; 4. Pregnant women; 5. Confirmed or suspected acute mesenteric ischemia and Raynaud's phenomenon; 6. Organ transplantation; 7. Shock caused by non infectious factors; 8. Hyperthyroidism; 9. Serious arrhythmia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of SOFA score 7 days after admission;Time of deviating from vasoactive drugs;Time of MAP reaching standard after medicationr administration;Use of open-label vasoactive drugs;Serious adverse events during medication;ICU length of stay; | — |
Countries
China
Contacts
Public ContactAijun Pan
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Outcome results
None listed