postoperative analgesia
Conditions
Interventions
Dexamethasone group:Dexamethasone 5mg and normal saline in 20ml normal saline in a 20 ml syringe intravenously by a pump with speed as 60ml/h
Dexmedetomidine:Dexmedetomidine 0.5ug/kg and normal saline in 20ml normal saline in a 20 ml syringe intravenously by a pump with speed as 60ml/h
Dexamethasone+Dexmedetomidine:Dexmedetomidine 0.5ug/kg and Dexamethasone 5mg and normal saline in 20ml normal saline in a 20 ml syringe intravenously by a pump with speed as 60ml/h
Saline:Normal saline in 20ml syringe intravenously by a pump with speed as 60ml/h
Sponsors
Haikou Orthopedics and Diabetes Hospital, Shanghai People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Aged between 18 and 70 years, both genders, primary major knee arthroscopic surgeries, defined as all knee arthroscopic surgeries except meniscus surgery; BMI:19-35; ASA I-III.
Exclusion criteria
Exclusion criteria: Patients with hypotension, bradycardia, presence of 1st, 2nd or 3rd degree heart block, hyperthyroidism, patients on adrenoreceptors agonist or antagonist therapy, with known hypersensitivity to local anaesthetic, pregnant women and preexisting peripheral neuropathy, were excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The duration of analgesic time; | — |
Secondary
| Measure | Time frame |
|---|---|
| The total consumption of analgesics within postoperative;The duration of sensory block;The duration of motor block;Postoperative nausea and vomiting;Patients satisfaction rates; | — |
Countries
China
Contacts
Public ContactXue Xiaoyun
Haikou Orthopedics and Diabetes Hospital, Shanghai People's Hospital
Outcome results
None listed