Nasopharyngeal Carcinoma
Conditions
Interventions
Gold Standard:Response Evaluation Criteria in Solid Tumors(RECIST)
(1) Complete Response,CR (2)Partial Response,PR (3)Stable Disease,SD (4)Progressive Disease,PD
Test 
Sponsors
Nanfang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Locally advanced and/or metastatic nasopharyngeal carcinoma confirmed by histology and/or cytology; 2. Failure of the first-line of comprehensive treatment or tumor progression (if recurrence or metastasis occurs during neoadjuvant chemotherapy followed by radiotherapy or within one year after completion, the first-line comprehensive treatment is considered to be unsuccessful); 3. Aged 18-75 years; 4. Clearly measurable lesions assessed as required by RECIST 1.1; 5. Eastern cooperative oncology group performance scores (ECOG-PS)of 0-1;
Exclusion criteria
Exclusion criteria: 1. Patients undergoing concurrent chemoradiotherapy and having undergone radiotherapy for less than half a year or during the study; 2. Requirement for surgery, intervention, radiofrequency ablation and other tumor treatment or targeted antibody drug therapy during the study; 3. Immunodeficiency or severe myelosuppression; 4. Severe liver and kidney disease, cardiovascular disease, blood disease, etc.; 5. Illegal use of drugs or chronic alcohol abuse or total daily alcohol intake > 50 g/d; 6. Lack of autonomy, inability to walk, or inability to participate in 6 months of follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Half Maximal Inhibitory Concentration;tumor lesion diameter length;Progress Free Survival,PFS;Progress Free Survival,PFS;Disease Control Rate,DCR;Overall survival,OS;Specimen Evaluability Rate;SEN, SPE, ACC, AUC of ROC;Kappa; | — |
Countries
China
Contacts
Public ContactLi Gang
Nanfang Hospital of Southern Medical University
Outcome results
None listed