Major depressive disorder
Conditions
Interventions
Es single drug group:Escitalopram 10-20mg/day, once a day, PO
Es+SFN group:Escitalopram 10-20mg/day, once a day, PO+Sulforaphane (ZHIYINGUOSU, Shenzhen Fushan Biotech Co., Ltd.) 4~6tablets/day (be equivalent to glucosinolates 274~411 µ mol), twice a day, PO
Es+rTMS group:Escitalopram 10-20mg/day, once a day, PO+rTMS Left dorsolateral prefrontal lobe,once a day, twenty times
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 18-60 years; 2) meeting the diagnostic criteria of major depressive disorder in DSM-5; 3) first-episode or recurrent, and no or poor response after sufficient treatment with antidepressants (except escitalopram) for at least 4 weeks (the reduction rate of Hamilton Depression scale (HAMD-17) score is less than 20% compared to the baseline). 4) haven't received electroconvulsive therapy (ECT or MECT), rTMS and other physical therapy in recent one month; 5) the score of Hamilton Depression scale (HAMD-17)>=17; 6) sufficient audio-visual and understanding ability; 7) sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Suffering from serious and active physical illness that may interfere with the treatment of the study at present (abnormal index > 2 times the normal value); 2) a history of another DSM-IV Axis I disorder (e.g., bipolar disorder, schizophrenia, schizoaffective disorder, and autism disorder); 3) obvious suicidal ideation, attempt or behavior (e.g., score of item 3 of HAMD-17 >= 3); 4) current pregnancy or breastfeeding, or those who plan to conceive. 5) those who have recently taken vitamins, immunosuppressants and other related drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| nuclear factor erythroid-2-related factor 2;Niacin skin flushing response; | — |
Secondary
| Measure | Time frame |
|---|---|
| p-Nrf2;MDA;GPx;SOD; | — |
Countries
China
Contacts
Public ContactXiaohua Liu
Shanghai Mental Health Center
Outcome results
None listed