Parkinson's disease
Conditions
Interventions
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. in line with the diagnosis of PD with constipation; 2. aged 40-75 years old; 3. before treatment, the use of a variety of treatment methods constipation no significant improvement; 4. colonoscopy without obvious organic disease; 5. understand and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Accompanied by other acute infectious diseases such as viral hepatitis, tuberculosis infection, etc.; 2. Constipation symptoms last less than 6 months; 3. Moderate or severe chronic obstructive pulmonary disease; 4. Hepatic and renal dysfunction; 5. Patients with severe hypertension and cerebrovascular accidents; 6. Patients with congestive heart failure and unstable angina; 7. Accompanied by other serious diseases that may hinder their enrollment or affect their survival, such as cancer or AIDS, anxiety, depression, mental or legal disability; 8. Doubt or indeed have a history of alcohol/drug abuse; 9. Women of childbearing age who are pregnant during the study period; 10. There are contraindications for colonoscopy, such as intestinal perforation, intestinal obstruction, etc.; 11. Other patients considered by the investigator to be unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut flora composition;MDS-UPDRS;Sutset of blood immune cells;Gene expression of gut mucosa; | — |
Countries
China
Contacts
Public ContactJie Liu
Huashan Hospital, Fudan University
Outcome results
None listed