Study for Individual Sensitivity to propofol

Brain Network Study of Mechanism of General Anesthesia - Difference in Propofol Sensitivity

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900027054

Enrollment

Unknown

Registered

2019-10-30

Start date

2018-06-01

Completion date

Unknown

Last updated

2019-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

high sensitivity group :None

low sensitivity group :none

Eligibility

Sex/Gender

Male

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Male aged 18 and 45 years; 2. Body Mass Index (BMI) is between 18 and 36; 3. There are no major physical illnesses (heart disease, hypertension, diabetes, malignant tumors, etc.) at present or in the past; 4. ASA <=2

Exclusion criteria

Exclusion criteria: 1. alcohol abuse (average daily greater than 150g); 2. Hearing impairment; 3. Currently receiving any medication 4. Received general anesthesia in the past six months 5. Long-term treatment of painkillers or recent history of painkillers; 6. Have a history of allergic reactions to non-steroidal anti-inflammatory drugs, lidocaine, ropivacaine, and opioids; 7. With history of mental illness, sedative and hypnotic drugs (benzodiazepines, barbiturates) or prescription-based sleep aids in the past month.

Design outcomes

Primary

Measure	Time frame
Individual sensitivity to propofol;Preoperative EEG measures;	—

Secondary

Measure	Time frame
STAI score;Propofol consumption;Behavioral measures;	—

Countries

China

Contacts

Public ContactWang Qiang

The First Affiliated Hospital of Xi’an Jiaotong University

dr.wangqiang@139.com+86 18049286968

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026