Role of SERTRALINE (SSRI) Versus DULOXETINE (SSNRI) among depressed total knee arthroplasty candidates: a prospective, randomized, patient selective, double blind study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900027004

Enrollment

Unknown

Registered

2019-10-28

Start date

2019-10-30

Completion date

Unknown

Last updated

2020-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty

Interventions

A:DULOXETINE

B:SERTRALINE

C:placebo

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with knee joint replacement who meet the criteria for BDI-2, under 80 years of age, and normal primary organ function

Exclusion criteria

Exclusion criteria: Patients take medication contraindications or/and patients who are already taking the above drugs.

Design outcomes

Primary

Measure	Time frame
depression index (HAS, BDI-2);VAS;complication;	—

Secondary

Measure	Time frame
knee function (HHS, ROM);	—

Countries

China

Contacts

Public ContactZongke Zhou

West China Hospital, Sichuan University

zhouzongke@scu.edu.cn+86 18980601028

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026