Sepsis
Conditions
Interventions
Experiment group:Caspofungin (inject) first dose 100mg QD, maintenance 70mg QD
Control group:Caspofungin (inject) first dose 70mg QD, maintenance 50mg QD
Sponsors
The First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Meet the diagnostic criteria of septic shock in sepsis 3.0; 3. Satisfy the 2 points above, and any condition in the following criteria of suspected invasive candidiasis: (1) Administrating broad spectrum antibiotics >= 4 days but no significant improvement of infection in the last 7 days; (2) Candida score >= 3 points; (3) Multiple Candida spp. colonization; (4) G-test >= 80pg/ml; (5) ICU length of stay >= 4 days, mechanical ventilation (1-3 days), central venous catheter indwelling (1-3 days) and any conditions in the followinga. a. TPN (1-3 days); b. major surgery (in 7 days); c. CRRT(1-3 days; d. SAP(in 7 days).
Exclusion criteria
Exclusion criteria: 1. Dying state patients who expect to die or discharge or terminate life support in 48 hours; 2. Administrating echinocandin >= 1 days or other antifungal drugs >= 48 hours 7 days before enrollment; 3. Proven allergic or intolerant to echinocandin, unable to receive the treatment; 4. Agranulocytosis (WBC < 0.5x10^9 /L); 5. Bone marrow or organ transplantation; 6. Chemotherapy in the last 3 months; 7. Receiving immunosuppressive treatment, apart from prednisone < 2mg/kg/d or equivalent steroids; 8. Severe live function abnormalities (Child class C); 9. AIDS; 10. Pregnant or lactating female; 11. Participating in other clinical trails 1 month before enrollment, or already enrolled in this trail before.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fAUC?Cmax?Cmin;28-day candidiasis-free survival; | — |
Countries
China
Contacts
Public ContactLi lifen
The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed