preeclampsia
Conditions
Interventions
Experimental group:40 mg of esomeprazole+Standard treatment
control group:Standard treatment
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Pregnant women that agree to participate in the trial and meet all the following conditions: 1. Gestational age between 26 + 0 weeks and 33+ 6 weeks; 2. Diagnosis of pre-eclampsia, gestational hypertension with evidence of preeclampsia, undefined hypertension with proteinuria; 3. No suspicions of major fetal anomaly or malformation (Major fetal anomaly is defined as anomalies or malformations that create significant medical problems for the patient or require specific surgical or medical management. Major anomalies or malformations are not considered a variation of the normal spectrum); 4. Estimated fetal weight by ultrasound >=500g; 5. Agree for expectant management and standardized care.
Exclusion criteria
Exclusion criteria: Patients that are unwilling to give consent, or present any of the following at presentation: 1. Having a history of eclampsia; 2. Termination of pregnancy at one's own request; 3.Cerebrovascular accident; 4. Severe renal or hepatic impairment presented as creatinine level of greater or equal to 125 µmol/l or liver transaminases greater than or equal to 500 IU/L; 5. Pulmonary edema; 6. Signs of left ventricular failure; 7. Disseminated intravascular coagulation defined as an INR greater than 2; 8. Platelet count at presentation less than 50x10^9; 9. Previous hypersensitivity reaction or contraindications to the use of PPIs; 10. Current use of a drug that may be affected by PPIs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gestational weeks; | — |
Secondary
| Measure | Time frame |
|---|---|
| sFLt-1;sENG; | — |
Countries
China
Contacts
Public ContactXiaolin Hua
Shanghai First Maternity and Infant Hospital
Outcome results
None listed