None
Conditions
Interventions
high sensitivity group:Propofol injection
low sensitivity group:Propofol injection
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 65 years or older; 2. ASA Physical Score I-IV; 3. Mentally competent and able to give consent for enrollment in the study; 4. Scheduled to undergo elective non-cardiac surgeries under general anesthesia; 5. Scheduled to stay in hospital for > 3 days after surgery.
Exclusion criteria
Exclusion criteria: 1. Hepatic and renal dysfunction; 2. Preoperative cognitive impairment characterized by Mini-Mental State Examination (MMSE) of 23 or less; 3. Preoperative history of stroke, schizophrenia, major depression, Parkinson's disease, alcohol and/or drug abuse, epilepsy, or dementia; 4. Inability to complete auditory experiments due to language difficulties, significant hearing or visual impairment; 5. Scheduled for surgery above the neck, cardiac, brain, or emergency surgery; 6. Patients who are participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Individual sensitivity to propofol;Preoperative EEG measures; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE score;GDS score;STAI score;Propofol concentration;Propofol consumption;Demographic characteristics;Behavioral measures; | — |
Countries
China
Contacts
Public ContactYan Fei
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed