Coronary Artery Disease
Conditions
Interventions
the experimental group:atorvastatin and metformin
the control group:atorvastatin and placebo
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-80 years, male or female; (2) Those who have definite diagnosis of coronary heart disease, including a previous history of PCI or CABG, coronary angiography or coronary CTA with at least one major artery stenosis greater than 50%. Troponin T 300mg/L; (4) Before admission, the patient or the patient's family should sign an informed consent.
Exclusion criteria
Exclusion criteria: (1) Those who are allergic to statins or metformin; (2) Those who are using other lipid-lowering drugs except statins and ezetimibe, including PCSK9 inhibitors, niacin, bette, etc; (3) Those who have malignant tumor, tuberculosis and other systemic wasting diseases; (4) Those who have severe liver (ALT > 3 times higher than the normal upper limit), kidney (above CKD3 stage) or unexplained CK elevation > 3 times higher than the normal upper limit; Uncontrolled rheumatic immune disease, long-term use of glucocorticoid; (5) Those who have chronic end-stage heart failure; (6) patients with severe trauma or major surgery; (7) Those who are definitely diagnosed with diabetes or HbA1c >6.5%; (8) Those who are in acute phase of various infectious diseases; (9) Those who are attacked by hyperthyroidism or hypothyroidism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| complete set of blood lipids; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI;fasting blood-glucose;HbA1C;Liver function;renal function;creatine kinase;blood routine examination;serum PCSK9 concentration; | — |
Countries
China
Contacts
Public ContactDaoquan Peng
The Second Xiangya Hospital of Central South University
Outcome results
None listed