cancer
Conditions
Interventions
1:CAR-T
2:PD-1/PD-L1 inhibitor
3:PD-1/PD-L1 inhibitor
4:immunotherapy
5:immunotherapy + microbial intervention
Sponsors
The Tenth People' s Hospital, Medical School of Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Gender is not limited; 3. Lymphoma patients, malignant melanoma or lung cancer patients who meet the CAR-T or PD-1/PD-L1 inhibitor treatment indications, specifically Lymphoma group: relapsed refractory B cell lymphoma, currently unable to perform stem cell transplantation, tumor cell CD19 expression positive; Malignant melanoma group: melanoma that cannot be surgically removed or metastatic; Lung cancer group: metastatic non-small cell lung cancer with disease progression or ineffective after chemotherapy and without EGFR or ALK mutation; 4. The expected lifetime is more than 3 months; 5. ECOG (Eastern Cooperative Oncology Group, ECOG) has a fitness score of 0 to 2; 6. Blood test:HB >= 80g/L, ANC >= 1x10^9/L, PLT>= 50x10^9/L; 7. Patients must be able to sign informed consent and be able to understand the possible risks associated with micro-ecological interventions; 8. Willing to provide stool, blood and tumor biopsy on time.
Exclusion criteria
Exclusion criteria: 1. Patients who have difficulty swallowing or have gastrointestinal obstruction; 2. Patients with autoimmune diseases, or extremely low immunity, or other diseases requiring systemic use of immunosuppressive drugs or hormones; 3. Human immunodeficiency virus (HIV)-positive or active hepatitis B or C infection; 4. Pregnant or lactating women; 5. The investigator has assessed that the study is not conducive to the patient and is not suitable for other situations in which the study was conducted.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of tumor therapy efficacy based on RECIST1.1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiome;Fecal metabolomics;Immune factor; | — |
Countries
China
Contacts
Public ContactLi Ning
The Tenth People's Hospital, Medical School of Tongji University
Outcome results
None listed