neck cancer/lung cancer/esophageal cancer
Conditions
Interventions
Experimental group:Subcutaneous injection was performed 48 hours after the end of chemotherapy
The control group:rhG-CSF was used with ANC<1.0×10^9/L during chemotherapy
Sponsors
Shandong Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years and = 20%, or 10% =1.5 x 10^9 /L, platelet count >= 80 x 10^9 /L, Hb >= 90 g/L, and no bleeding tendency; 7. The patient needs to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. The patient currently has an uncontrolled infection, or has received systemic antibiotics within 72 hours of receiving chemotherapy; 2. Any patient with abnormal bone marrow hyperplasia and other hematopoietic dysfunction; 3. Patients who have received bone marrow or hematopoietic stem cell transplantation in the past 3 months; 4. Patients with previous malignant tumors that have not been cured or have brain metastases; 5. Liver function tests found that total bilirubin (TBIL), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were >2.5 times the upper limit of normal; 6. Renal function tests found that serum creatinine (Cr) was >1.5 times the upper limit of normal; 7. Patients who are allergic to this product or other genetically engineered E. coli-derived biological products; 8. The patient who has a mental or neurological disorder and cannot cooperate; 9. Researchers believe patients are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of grade III /IV neutropenia in each cycle of chemotherapy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of febrile neutropenia (FN) in each cycle of chemotherapy;Dose adjustment ratio of chemotherapeutic drugs and radiotherapy caused by neutropenia during each chemotherapy cycle;Incidence of treatment interruption by cycle (including chemotherapy and radiotherapy);Incidence and duration of grade III or above oral mucositis in each cycle; | — |
Countries
China
Contacts
Public ContactBaosheng Li
Shandong Cancer Hospital
Outcome results
None listed