Effect of sevoflurane on renal barrier function during extracorporeal circulation

Protection of endothelial glycocalyx during extracorporeal circulation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900026882

Enrollment

Unknown

Registered

2019-10-25

Start date

2019-12-01

Completion date

Unknown

Last updated

2019-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

extracorporeal circulation

Interventions

1:Sevoflurane

2:Propofol

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Patients undergoing elective cardiac surgery under extracorporeal circulation were selected.

Exclusion criteria

Exclusion criteria: Secondary surgery history, sandwich, pregnant women, hemodynamic instability (need to maintain vascular active drugs), severe liver disease (alanine aminotransferase and aspartate aminotransferase > 150 u), renal insufficiency (creatinine > 1.5 mg/dl), chronic obstructive pulmonary disease (forced expiratory volume in 1 second is less than 0.8 L), nervous system, carotid stenosis, severe infection patients (calcitonin > 0.5 ug/L, CRP is greater than 8.5) and diabetes.

Design outcomes

Primary

Measure	Time frame
glycocalyx;	—

Countries

China

Contacts

Public ContactWeijian Wang

The First Affiliated Hospital of Wenzhou Medical University

wangwj2002@hotmail.com+86 13806683232

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026