diarrhea-predominant irritable bowel syndrome(IBS-D)
Conditions
Interventions
Control group:Placebo
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for randomized controlled trials of patients with dampness pattern syndrome 1 those who meet the diagnostic criteria for IBS-D in Rome IV; 2. those who meet the diagnostic criteria of Chinese medicine pattern of dampness; 3. aged 18 to 70 years; 4. initial IBS-SSS score > 75; 5. basic the ability of reading comprehension; 6. patients have informed consent and signed informed consent. Inclusion criteria for observational study of patients with non-dampness syndrome 1 those who meet the diagnostic criteria for IBS-D in Rome IV; 2. those who meet the diagnostic criteria of Chinese medicine pattern of non-dampness; 3. aged 18 to 70 years; 4. basic the ability of reading comprehension; 5. patients have informed consent and signed informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for randomized controlled trials of patients with dampness syndrome 1. patients with heart, liver, kidney, hematopoietic system and other serious diseases and tumors, have a history of nervous system and mental illness; 2. patients with warning signs (weight loss within 3 months of emaciation > 10%), hematochezia that is confirmed not to be caused by hemorrhoids or anal fissure , diarrhea at night, fever, family history of colorectal cancer (or polyposis syndrome), inflammatory bowel disease (IBD) or celiac disease. 3. organic diseases of the digestive system, or systemic diseases that affect digestive tract dynamics; 4. patients with a history of abdominal surgery (except caesarean section); 5. those who are unwilling or unable to stop using drugs that affect the effectiveness evaluation of interventions during the study; 6. pregnant and nursing women or women planning pregnancy within 3 months; 7. those who have participated in other clinical trials in the past 3 months; 8. standard points of SAS.>50, standard points of SDS.>53; 9. ALT or AST is 2 times higher than the upper limit of normal range., TBIL or BUN is 1.5 times higher than the upper limit of normal range. 10. patients with a history of drug allergy used in the study; 11. researchers believe that patients are not suitable for this study. Exclusion criteria for observational study of patients with non-dampness syndrome 1. pregnant and nursing women or women planning pregnancy within 3 months; 2. those who have participated in other clinical trials in the past 3 months; 3. standard points of SAS.>50, standard points of SDS.>53; 4. researchers believe that patients are not suitable for this study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| IBS-QOL;TCM syndrome and signs;EQ-5D-5L;IBS-SSS; | — |
Primary
| Measure | Time frame |
|---|---|
| response rate of adequate relief (AR); | — |
Countries
China
Contacts
Public ContactZehuai Wen
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed