Periodontitis and end-stage renal disease
Conditions
Interventions
experimental group:immediate non-surgical periodontal treatment
control group:delayed non-surgical periodontal treatment
Sponsors
The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) The age is between 18 and 80 years; (2) GFR < 15ml/ (min.1.73m2) and undergoing peritoneal dialysis or hemodialysis; (3) Moderate and severe periodontitis according to CDC/AAP criteria; (4) At least 10 natural teeth; (5) Not experience any periodontal treatments within 6 months before our trial.
Exclusion criteria
Exclusion criteria: (1) Immunosuppressants or antibiotics use more than 7 days within one month prior to recruitment; (2) During pregnancy, lactation or planning to become pregnant during the study period (3) Severe complications (such as metastatic cancer) and dementia that may affect life expectancy within 1 year. (4) Serious oral diseases that interfere with periodontal treatment, such as acute pulpitis. (5) Some contraindications of dental treatment according to clinicians'judgement. (6) Systemic or obvious local signs of infection / inflammation (PCT> 2ng/ml). (7) Abnormal liver function (AST/ALT > 3 times the normal upper limit).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hepcidin; | — |
Secondary
| Measure | Time frame |
|---|---|
| 25-hydroxyvitamin D;ferritin;cholesterol;serum albumin;hs C-reactive protein;procalcitonin;CD14;MMP-9;IL-1ß;IL-6;TNFa;????;LPS;hemoglobin; | — |
Countries
China
Contacts
Public ContactHaixia Lu
Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed