breast cancer
Conditions
Interventions
group according to chemotherapy and basic conditions (very high risk group, high risk group, moderate risk group, low risk group, very low risk group):N/A
Sponsors
Sichuan Provincial People's Hospita
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Female aged 18-75 years; 2) Preoperative histopathological diagnosis confirmed breast cancer. 3) Neoadjuvant or adjuvant chemotherapy is planned according to the judgement of the researchers. 4) Echocardiography or radionuclide angiography (MUGA) showed that left ventricular ejection fraction was more than 55%. 5) ECOG score 0-2; 6) Ability and willingness to sign informed consent; 7) Voluntary participation, good compliance, can be followed up; 8) The function of bone marrow and main organs is basically normal. Blood routine: white blood cell (WBC) > 4.0 *10^9/L, neutrophil count (ANC) > 1.5 *10^9/L. B. Hemoglobin (HgB) > 100g/L, platelet (PLT) > 80 *10^9/L; C. Liver function: aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) = 2.5N, and serum total bilirubin 60ml/min).
Exclusion criteria
Exclusion criteria: 1) Breast cancer patients who do not receive chemotherapy (targeted therapy only). 2) According to the judgement of the researchers, the patients with other serious diseases can not tolerate chemotherapy. 3) Pregnant or lactating women. 4) Mental disorders or mental disorders, poor compliance. 5) Interruption of treatment for any reason can not complete the course of chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular global long-axis strain;Incidence of cardiotoxicity; | — |
Countries
China
Contacts
Public ContactLiu Jinping
Sichuan Provincial People's Hospital
Outcome results
None listed