Dexmedetomidine premedication reduces postoperative inflammatory response in children for day surgery: a randomized controlled trial

Study on clinical value of dexmedetomidine in comfortable medical treatment of perioperative period in school age children

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900026795

Enrollment

Unknown

Registered

2019-10-22

Start date

2019-10-28

Completion date

Unknown

Last updated

2019-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Indirect inguinal hernia

Interventions

C group:No preoperative medication

M group:Premedication of midazolam

D group:Premedication of dexmedetomidine

Eligibility

Sex/Gender

All

Age

6 Years to 11 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria were as follows: Aged 6 to 11 years children, with American Society of Anesthesiologists (ASA) physical status I and II scheduled for elective hernia repair under general anesthesia.

Exclusion criteria

Exclusion criteria: Complicated hernia, a known allergy or hypersensitive reaction to dexmedetomidine or midazolam, long-term use of sedative or analgesic drugs, a past history of surgery or anesthesia, current upper respiratory infections, asthma, developmental delay, psychological diagnosis requiring active treatment, or congenital or neurological diseases.

Design outcomes

Primary

Measure	Time frame
TNF-a;IL-6;NLR;	—

Secondary

Measure	Time frame
Anxiety scores;pain scores;	—

Countries

China

Contacts

Public ContactZhen Du

Hunan Children's Hospital

meggyzhen@163.com+86 13574114910

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026