Heart Failure with preserved Ejection Fraction
Conditions
Interventions
Gold Standard:At present, there is no gold standard to diagnose HFPEF in clinic, so this study takes clinical diagnosis of HFPEF as reference standard, that is, 1) it has typical symptoms and signs of
2) LVEF >= 50%, and left ventricle is not large
3) diastolic dysfunction of left ventricle co
Index test:1. Direct Flow
2. Delayed Ejection
3. Retained inflow
4. Residual Volume.
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The admission criteria of HFpEF patients were as follows: 1) they had typical symptoms and signs of heart failure; 2) LVEF >= 50%, and left ventricle was not large; 3) diastolic dysfunction of left ventricle confirmed by tissue Doppler: mean e '= 13. 2. Criteria for HFrEF patients: 1) typical symptoms and signs of heart failure, more than 3 months; 2) LVEF < 40%. 3. The admission criteria of healthy recipients: 1) the patients and their families voluntarily accept the examination; 2) the research scheme will be implemented after being approved by the hospital ethics committee.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for HFpEF and HFrEF patients: heart valve disease, pericardial disease, hypertrophic cardiomyopathy, restrictive cardiomyopathy, any contraindications of CMR scan, aged less than 20 years or more than 70 years, malignant tumor patients, pregnant women. 2. Exclusion criteria for healthy volunteers include: 1) history of hypertension, whether or not using drugs; 2) history of diabetes, whether or not using drugs; 3) history of any cardiovascular disease, including ischemic and non ischemic cardiomyopathy, valvular heart disease, congenital heart disease; 4) any contraindications of CMR scanning; 5) age less than 20 years or more than 70 years; 6) malignant Tumor patients; 7) pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| directe flow;Delayed Ejection;Retained inflow;SEN, SPE, ACC, AUC of ROC; | — |
Secondary
| Measure | Time frame |
|---|---|
| Residual Volume; | — |
Countries
China
Contacts
Public ContactTang Guangyu
Shanghai Tenth People's Hospital
Outcome results
None listed