Randomized controlled study of tracheal intubation condition at different time point after mivacurium injection

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900026781

Enrollment

Unknown

Registered

2019-10-22

Start date

2019-11-01

Completion date

Unknown

Last updated

2019-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tracheal intubation

Interventions

90s group:Tracheal intubation 90 s after mivacurium injection

180s group:Tracheal intubation 180 s after mivacurium injection

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for short time operation under general anesthesia with tracheal intubation(estimated operation time <1h); 2. aged 18-65 years; 3. American Society of Anesthesiologists (ASA) grade I-II; 4. Mallampati airway grade I-II; 5. Signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Heavy long-term smokers, alcoholics, drug addicts and mental disorder patients; 2. Severe respiratory system diseases, COPD, asthma, hyperresponsive airway condition; 3. Severe cardiovascular system diseases, such as coronary heart disease, severe valvular heart disease, etc. 4. Abnormal liver and kidney function; 5. Serious electrolyte imbalance; 6. Neuromuscular diseases, patients who have used neuromuscular blockers within one week, patients who have recently used medicine that interfere with neuromuscular excitation conduction, such as antiepileptics, hormones, furosemide, aminoglycoside antibiotics, etc; 7. Mouth opening less than 3 fingers, abnormal neck movement, chin nail distance less than 6cm, difficult airway; 8. High risk of aspiration; 9. Previous allergy to mivacurium or other muscle relaxants; 10. Known plasma cholinesterase deficiency; 11. During pregnancy or lactation; 12. Patients who have participated in any other drug clinical trials within 30 days before the start of the study; 13. Other conditions not suitable for inclusion.

Design outcomes

Primary

Measure	Time frame
Proportion of patients in each group with excellent intubation condition;	—

Secondary

Measure	Time frame
MAP;HR;SpO2;Skin flushing;lung wheezing rale;Cormack-Lehane grade;Cooper 's tracheal intubation scores;	—

Countries

China

Contacts

Public ContactXiaoguang Zhang

Zhongshan Hospital of Fudan University

zhangxg@fudan.edu.cn+86 13641995733

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026