Mental disorders
Conditions
Interventions
Sponsors
The First Hospital of Shanxi Medical Unversity
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Affective disorder 1. Be able to cooperate with all study procedures and sign informed consent to participate in the study voluntarily. 2. Have high compliance and were able to follow up on time. 3. Aged 18 to 55 years. 4. Meet the DSM-5 diagnostic criteria (using the concise international neuropsychiatric interview MINI) for depressive episodes and bipolar disorder (or who meet the ICD-10 diagnostic criteria for moderate and major depressive episodes/bipolar disorder diagnostic criteria) and can cooperate with treatment. 5. Never use drugs regularly. First episode schizophrenia 1. Be able to cooperate with all study procedures and sign informed consent to participate in the study voluntarily. 2. Have high compliance and were able to follow up on time. 3. Aged 18 to 55 years. 4. Meet the DSM-5 diagnostic criteria (using the concise international neuropsychiatric interview MINI) for schizophrenia (or who meet the ICD-10 diagnostic criteria for schizophrenia) and can cooperate with treatment. 5. Positive and negative symptom scale (PANSS) score at >= 60 points at screening visit and baseline visit. 6. Never use drugs regularly. 7. If a drug is being used but the clinician thinks a change is needed (poor efficacy or intolerance).
Exclusion criteria
Exclusion criteria: Affective disorder 1. Psychiatric history Do not exclude other organic or medically induced secondary depressive disorder, or bipolar disorder. Have severe suicidal or impulsive tendencies at present. Have a history of other serious mental disorders. Have evidence of alcohol or other substance dependence or abuse. 2. Other medical history Have serious physical diseases and organic brain diseases. Have a serious disease of the body or nervous system revealed by laboratory or physical examination that had not been eliminated. 3. Medical history Take drugs that have central nervous system effects or that may affect mood with long-term. 4. Childbearing history Woman who is pregnant or lactating. 5.Others Have a contraindication to MRI. Participated in other clinical trials within 30 days. First episode schizophrenia Do not exclude other organic or medically induced secondary depressive disorder, or bipolar disorder Have severe suicidal or impulsive tendencies at present. Have a history of other serious mental disorders. Have evidence of alcohol or other substance dependence or abuse. 2. Other medical history Have serious physical diseases and organic brain diseases. Have a serious disease of the body or nervous system revealed by laboratory or physical examination that had not been eliminated. 4. Childbearing history Woman who is pregnant or lactating. 5.Others Cannot take medication as prescribed or do not have guardians. Have a contraindication to MRI. Participated in other clinical trials within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive function;cognitive function;psychologic status;Head mri;electroencephalography; | — |
Countries
China
Contacts
Public ContactXinrong Li
The First Hospital of Shanxi Medical Unversity
Outcome results
None listed