Asthma
Conditions
Interventions
Intervention Group:When AQI > 200, the intervention group was given budesonide / formoterol twice a day until AQI < 200.
Control group:Keep original status without intervention
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years old, male and female; 2. non-acute attack patients who meet the diagnostic criteria of asthma patients according to GINA guidelines 2017, 3. quit smoking for more than 6 months; 4. be able to engage in daily activities; 5. willing to participate in this study and to follow the research programme, Ability to sign informed consent; 6. Beijing residents, air pollution monitoring points within 3 km of the address; air pollution monitoring points within 3 km of the unit where the non-retired subject is located; 7. communication equipment at home.
Exclusion criteria
Exclusion criteria: 1. chronic respiratory diseases other than asthma have been diagnosed, Chronic obstructive pulmonary disease, lung cancer, tuberculosis, bronchiectasis, diffuse lung disease (interstitial pneumonia, occupational lung disease, sarcoidosis, etc.); 2. lobectomy and / or lung transplantation, pleural disease; 3. expected life. Life expectancy less than 3 years; 4. combined with severe underlying diseases (including severe mental illness, mental retardation, nervous system disease, malignant tumor, chronic liver disease, heart failure, autoimmune disease, chronic renal disease); 5. those who have never engaged in outdoor activities; 6. those who are expected to move out of the city within 2 years; 7. those who plan to carry out new indoor installations during the study period; 8. alcoholism, drug abuse or abuse of toxic solvents; 9. have a history of allergies or clear taboos to the study of drugs or their components. Certificate; 10. participating in other clinical trials; 11. unable to follow up for a long time or with poor compliance; 12. not signing informed consent; 13. excluding people at high risk of budesonide / formoterol, Such as osteoporosis, diabetes, etc.; 14. smoke age > 10 pack years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of acute asthma attacks per year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary function;Fractional exhaled nitric oxide; | — |
Countries
China
Contacts
Public ContactJunjun Hang
Peking University First Hospital
Outcome results
None listed