recurrent nasopharyngeal carcinoma
Conditions
Interventions
Sponsors
Eye, Ear, Nose, and Throat Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosed of recurrent nasopharyngeal carcinoma by pathology or imaging study; 2.Stage T1 or T2 according to AJCC 8th edition ; 3.Aged 18 to 70 years; 4.Without metastasis; 5.previously received 1 course of radiotherapy;Without radiotherapy within 1 year, without local treatment for recurrent disease; 6.Surgical resectable and IMRT suitable; 7.If regional recurrence presented, regional lesion can be treated with local treatments. 8.ECOG score 0 or 1; 9.Sufficient organ function; 10.Acceptable approach of contraception.
Exclusion criteria
Exclusion criteria: 1.Refuse to sign inform consent; 2.Radiation encephalopathy or leptomeningeal disease (LMD); 3.History of radioactive particle planting; 4.Have uncontrolled intercurrent illnesses which will interfere with the ability to undergo therapy; 5.With prior malignancy (excluding adequately treated basal cell or squamous cell skin cancer, in-situ cervical cancer); 6.Any contradiction to surgery; 7.Have any co-existing condition that would preclude full compliance or safety with the study; 8.Presence of a significant neurological or psychiatric disease, including dementia and seizures; 9.Uncontrolled infectious diseases; 10.Female patients who are at pregnancy or lactation. 11.Without personal freedom or independent civil capacity. 12.With serious autoimmune disease. 13.Participants of other interventional clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3 year overall survival (OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| progression free survival;Local progression free survival;Regional progression free survival;Distant metastasis free survival;Toxicities;life quality; | — |
Countries
China
Contacts
Public ContactHongmeng Yu
Eye, Ear, Nose, and Throat Hospital, Fudan University
Outcome results
None listed