Depression
Conditions
Interventions
1:Vortioxetine Hydrobromide Tablets (Xin Da Yue)
1:Venlafaxine Hcl Sustained-Release Capsules (Yi Nuo Si)
Sponsors
Peking University Sixth Hospital, Peking University Institute of Mental Health
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. aged between 18 and 65 years (including 18 years, excluding 65 years); 2. the subject signed an informed consent form indicating that he understood the purpose and process of the test and was willing to participate in the test.the patient (or his legal representative/guardian) must sign an informed consent form; 3. comply with the diagnostic criteria for DSM-V depression; 4. Patient Health Questionnaire (PHQ-15) >= 10; 5. HAMD-17 >= 17; 6. right hand, has completed more than 9 years of compulsory education; 7. can take the study drug himself during the study period, or have a fixed helper to help with the medication; 8. did not take any drug treatment within 8 weeks before enrollment; 9. the number of MDQ positive entries 80;
Exclusion criteria
Exclusion criteria: 1. history of loss of consciousness caused by brain organic diseases or head trauma; 2. any major or unstable cardiovascular, respiratory, or nervous system (including epilepsy or obvious cerebrovascular disease), kidney, liver, endocrine or immune disease related history, including recent or current clinically significant laboratory abnormalities (blood, urine routine and blood biochemical tests); 3. known, clinically meaningful laboratory indicators or ECG abnormalities; suffering from any disease, liver disease or kidney disease that may alter the absorption, metabolism or excretion of the study drug; 4. there are serious suicidal ideations and behaviors, HAMD-17 suicide factor >= 3; 5. hearing problems (the words of the examiner cannot be heard or understood under normal conversation); 6. there are red, green, blue or yellow blind or weak; 7. patients who underwent ECT treatment within 3 months; 8. patients with significant mental retardation and seizure history; 9. history of abuse and dependence of psychoactive substances; 10. those who have used research drugs ineffective or have contraindications to research drugs; 11. have a history of manic episodes or a family history of bipolar disorder, repeated transient depressive episodes, dysthymia; 12. women during pregnancy and lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| physical symptoms;cognitive function;inflammatory cytokines 6/5000; | — |
Countries
China
Contacts
Public ContactShi Chuan
Peking University 6th Hospital, Peking University Institute of Mental Health
Outcome results
None listed