Reversible Cognitive Frailty
Conditions
Interventions
Exercise group:Exercise at home
Rehabilitation group:Rehabilitation at hospital
Exercise&Rehabilitation group:Exercise at home&Rehabilitation at hospital
control group:null
Sponsors
Huadong Hospital, Shanghai Medical College, Fudan University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Reversible cognitive frailty patient: pre-physical frailty and physical frailty (Fried score 1-5); meanwhile, subjective cognitive decline (Spain SCD-Q score 0-7); 2. Aged 60-90 years; 3. MMSE 27-30; 4. Subjects capable of understanding the protocol, complying with its requirements, and attending study visits.
Exclusion criteria
Exclusion criteria: 1. Disability or handicap; visual or hearing impairments in compatible with performance and/or interpretation of neuropsychological tests; 2. Other primary psychiatric/neurologic disorders,such as AD;severe depression or generalized anxiety; acute infection diseaseacute traumatic brain injuries, stroke(< 3 months), autoimmune disease, multiple organ failure, which could be life-threatening in the short term; 3. Missing informed consent; 4. No readiness to save and refer pseudonym personal data; 5. Any condition disturbing or making MRI and other measures impossible; 6. Alcohol or drug abuse; 7. Participation in any clinical trial < 3 months prior to screening or ongoing other clinical trials; 8. Other situation that researchers considered not suite to be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| subjective cognitive decline questionaire;Fried physical frailty score; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIA-AA MCI criterian;Mini-Mental State Examination; | — |
Countries
China
Contacts
Public ContactRuan Qingwei
Huadong Hospital, Shanghai Medical College, Fudan University
Outcome results
None listed