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The expression of PD-1, CD96, TIGIT and CD226 in NK cell and T cell predict the prognosis of sepsis: a prospective, multicenter, observational cohort study

The expression of PD-1, CD96, TIGIT and CD226 in NK cell and T cell predict the prognosis of sepsis: a prospective, multicenter, observational cohort study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900026678
Enrollment
Unknown
Registered
2019-10-18
Start date
2019-10-18
Completion date
Unknown
Last updated
2020-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

NK,&#32
T-cell&#32
PD-1/PD-L1,&#32
CD96,&#32
TIGIT,&#32
CD226
Index test:Peripheral&#32
blood&#32
Gold Standard:Clinical outcome

Sponsors

Guangdong Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) sepsis patients were diagnosed according to sepsis-3.0; (2) onset time of patients <=7 days.

Exclusion criteria

Exclusion criteria: (1) age < 18 years; (2) uremia, requiring long-term hemodialysis; (3) at the end of chronic diseases such as malignant tumors, the estimated survival time is less than 28 days; (4) patients with autoimmune diseases, immunodeficiency or long-term use of immunosuppressants; (5) pregnant women; (6) patients and their families do not agree to participate in the trial.

Design outcomes

Primary

MeasureTime frame
SEN, SPE, ACC, AUC of ROC;survival;—

Secondary

MeasureTime frame
Immunocheckpoint molecule on T cell;Immunocheckpoint molecule on NK cell;—

Countries

China

Contacts

Public ContactHongke Zeng

Guangdong Provincial People's Hospital

zenghongke@vip.163.com+86 13903012521

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026