Hypertension
Conditions
Interventions
Case series:Allisartan, amlodipine
Sponsors
The First Hospital of Jilin University
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Signed consent inform, acknowledge of content, procedure and potential adverse reactions of study; 2. Followed by study protocol and complete study; 3. Subjects (including their partners) have no pregnancy plan and voluntary to take effective contraceptive measures 4. Aged 18 to 45 years old (including 18 and 45 years old); 5. Body weight: Men >= 50kg, BMI=kg/m^2, 18-28 kg/m^2 (including 18-28 kg/m^2); 6. Normal hysical examination, vital sign or abnormal but no clinical significance. SBP 100~139, DBP 60~90.
Exclusion criteria
Exclusion criteria: 1. Amount of smoking >5 cigarets per day within 3 months prior to study; 2. Allergy to alisartan, losartan, amlodipine and their integridients; 3. History of drugs addicted and/or alcohol abuse (14 units of alcohol per week: 1 unit=285 mL of beer, or 25 mL of liquor, or 100 mL red wine); 4. Blood donation or blood lossing > 450mL prior to administration of drugs; 5. Difficulty in swallowing or history of any GI diseases affecting the absorption of drugs; 6. High risk in bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cmax;AUC; | — |
Countries
China
Contacts
Public ContactYanhua Ding
The First Hospital of Jilin University
Outcome results
None listed