antibiotic-associated diarrhea
Conditions
Interventions
placebo group:placebo
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~70 years old; 2. Antibiotic treatment =3 days; 3. Good gastrointestinal function; 4. Signing informed consent.
Exclusion criteria
Exclusion criteria: 1. Diarrhea occurred within 2 weeks before the trial; 2. Combined with digestive diseases that cause diarrhea, such as acute enteritis, radiation enteritis, ischemic colitis, ulcerative colitis, digestive tract tumors or allergic gastrointestinal syndrome; 3. Receiving immunosuppressive therapy or any disease that causes immunosuppression (including hematological malignancy, AIDS); 4. Long-term use of antibiotics before the trial; 5. Having received digestive surgery within 1 year prior to the trial or digestive surgery is planned; 6. Clostridium difficile infection was diagnosed 3 months before the trial; 7. Taking probiotics during the trial or within 15 days before the trial; 8. Tube feeding, gastrointestinal fistula or total parenteral nutrition; 9. Pregnant or lactating women; 10. Fecal incontinence; 11. Lactose intolerance; 12. Participating in other clinical trials; 13. Other circumstances not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of AAD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Defecation frequency;Fecal trait;Diarrhea duration;Stool routine examination;Intestinal flora analysis;Safety indicators such as liver and kidney function; | — |
Countries
China
Contacts
Public ContactZhiyong Rao
West China Hospital, Sichuan University
Outcome results
None listed