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A multicenter, double-blind, randomized, placebo-controlled trial for the effect of traditional Chinese medicine formula Dingkun pill on improving outcomes of IVF-ET in women with low prognosis

A multicenter, double-blind, randomized, placebo-controlled trial for the effect of traditional Chinese medicine formula Dingkun pill on improving outcomes of IVF-ET in women with low prognosis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026614
Enrollment
Unknown
Registered
2019-10-16
Start date
2019-11-15
Completion date
Unknown
Last updated
2019-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low prognosis

Interventions

DKP group:Dingkun pill should be administered on the 5th day of the menstrual cycle prior to controlled ovarian stimulation (COH), 7g each time, 3 times per day, until the oocyte retrieval day, a tota
Placebo group:Placebo should be administered on the 5th day of the menstrual cycle prior to controlled ovarian stimulation (COH), 7g each time, 3 times per day, until the oocyte retrieval day, a total

Sponsors

The Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
35 Years to 44 Years

Inclusion criteria

Inclusion criteria: Participants aged 35 to 44 years with poor prestimulation ovarian reserve parameters (AFC<5, AMH<1.2 ng/mL) and with an expected poor ovarian response which means fewer than four oocytes were retrieved after standard ovarian stimulation, will be recruited in this study.

Exclusion criteria

Exclusion criteria: BMI >= 30 Kg/m2, karyotyping abnormalities in both partners, endometriosis, hydrosalpinx, congenital or acquired dysplasia of the uterus and other contraindications for assisted reproductive technology.

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy outcome;—

Secondary

MeasureTime frame
Implantation rate;Early miscarriage rate;—

Countries

China

Contacts

Public ContactZhengao Sun

The Affiliated Hospital of Shandong University of Traditional Chinese Medicine

sunzhengao77@126.com+86 13708938621

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 27, 2026