severe traumatic brain injury
Conditions
Interventions
Experimental group:1. Maintain hemoglobin and plasma albumin infusion of less white erythrocytes or red blood cells, maintain hemoglobin 125 ~ 140g / L, infusion 20 ~ 25% albumin to maintain albumin 3
2. Reduce intracranial pressure Mainly by reducing cerebral perfusion pressure (CPP).
Control group:Dehydration and intracranial pressure reduction program based on hypertonic drugs such as mannitol
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. STBI patients: Glasgow coma score (GLS) 6 hours, or consciousness worsened and coma > 6 hours within 24 hours after injury; 2. aged 18 to 70 years old; 3. Patients who have intracranial pressure monitoring within 48 hours of onset.
Exclusion criteria
Exclusion criteria: 1. The cerebral perfusion pressure is less than 10mmHg after the patient arrives at the hospital; 2. GCS 3 points after the patient arrives at the hospital, the pupil is dilated and fixed; 3. Pregnancy or breastfeeding; 4. The estimated survival time of malignant tumors is less than 2 months; 5. Inability to obtain informed consent or authorization; 6. Participate in other exploratory clinical trials within 6 months prior to screening; 7. Cardiopulmonary resuscitation received within 72 hours prior to enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital stay, ICU time, hospitalization cost, mechanical ventilation time, APACHE II score, GCS score, mannitol dose, 60-day mortality, 28-day and 60-day GOS score (Glasgow Outcome Scale Glasgow Outcome Score); | — |
Countries
China
Contacts
Public ContactTongwen Sun
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed